Roderick H Dashwood Selected Research

sulforaphane

3/2021	Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells.
1/2020	Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial.
3/2018	Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.
1/2018	Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs.
1/2017	A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.
1/2017	Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer.
12/2015	Assessment of global proteome in LNCaP cells by 2D-RP/RP LC-MS/MS following sulforaphane exposure.
10/2015	Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells.
4/2015	Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention.
1/2015	Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.

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Roderick H Dashwood Research Topics

Disease

83	Neoplasms (Cancer) 12/2021 - 01/2002
32	Carcinogenesis 03/2021 - 05/2002
28	Colonic Neoplasms (Colon Cancer) 03/2021 - 09/2002
19	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 04/2006
9	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 08/2004
8	Polyps 03/2021 - 09/2002
6	Neoplasm Metastasis (Metastasis) 03/2021 - 12/2004
4	Inflammation (Inflammations) 01/2018 - 06/2011
3	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/2021 - 10/2004
3	Chronic Disease (Chronic Diseases) 09/2020 - 10/2007
3	Breast Neoplasms (Breast Cancer) 11/2009 - 03/2007
3	Aberrant Crypt Foci 01/2007 - 09/2002
2	Adenomatous Polyps 01/2021 - 01/2021
2	Adenoma (Adenomas) 01/2017 - 01/2006
2	Ulcerative Colitis 01/2017 - 01/2016
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 07/2013 - 01/2012
2	Cardiovascular Diseases (Cardiovascular Disease) 08/2012 - 10/2007
2	Genomic Instability 01/2011 - 01/2008
2	Lymphoma (Lymphomas) 08/2008 - 01/2006
2	Intestinal Polyps 10/2007 - 08/2002
1	Intestinal Neoplasms (Intestinal Cancer) 01/2021
1	Medulloblastoma 10/2020

Drug/Important Bio-Agent (IBA)

24	sulforaphaneIBA 03/2021 - 08/2004
24	Proteins (Proteins, Gene)FDA Link 10/2020 - 01/2002
19	Histone Deacetylases (Histone Deacetylase)IBA 03/2018 - 02/2006
18	PhytochemicalsIBA 12/2020 - 02/2003
17	Histones (Histone)IBA 01/2018 - 08/2004
16	beta CateninIBA 09/2009 - 01/2002
14	CarcinogensIBA 01/2017 - 02/2003
14	Histone Deacetylase InhibitorsIBA 01/2016 - 08/2004
13	TeaIBA 12/2010 - 05/2002
9	ChlorophyllIBA 03/2021 - 02/2003
9	Messenger RNA (mRNA)IBA 10/2016 - 02/2004
9	chlorophyllin (copper chlorophyll)IBA 11/2009 - 01/2003
8	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 10/2017 - 09/2002
7	RNA (Ribonucleic Acid)IBA 03/2021 - 10/2014
7	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2007
7	ChromatinIBA 01/2017 - 08/2004
7	AminesIBA 01/2017 - 05/2002
6	MicroRNAs (MicroRNA)IBA 01/2021 - 11/2011
6	CateninsIBA 01/2021 - 06/2012
6	benzocycloheptapyridineIBA 10/2017 - 01/2007
6	dibenzo(a,l)pyreneIBA 01/2017 - 01/2006
6	indole-3-carbinolIBA 07/2013 - 04/2003
5	Sulindac (Copal)FDA LinkGeneric 01/2021 - 09/2002
5	EnzymesIBA 03/2018 - 08/2004
5	PolyphenolsIBA 01/2017 - 01/2007
5	3,3'-diindolylmethane (diindolylmethane)IBA 01/2017 - 03/2007
5	AndrogensIBA 10/2014 - 04/2006
5	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 11/2009
4	Transcription Factors (Transcription Factor)IBA 01/2017 - 10/2004
4	Amino Acids FDA Link 10/2006 - 02/2003
3	histone deacetylase 3IBA 03/2021 - 01/2018
3	MutagensIBA 10/2020 - 06/2002
3	IsothiocyanatesIBA 01/2018 - 03/2007
3	Pharmaceutical PreparationsIBA 01/2017 - 02/2006
3	AntioxidantsIBA 04/2015 - 11/2004
3	Phosphotransferases (Kinase)IBA 01/2015 - 02/2006
3	isothiocyanic acidIBA 01/2011 - 04/2006
3	TCF Transcription FactorsIBA 09/2009 - 04/2003
3	Dimenhydrinate (DMH)FDA LinkGeneric 10/2006 - 02/2003
3	1,2-Dimethylhydrazine (1,2 Dimethylhydrazine)IBA 10/2006 - 02/2003
3	LigandsIBA 06/2006 - 02/2004
3	quinolineIBA 04/2003 - 01/2002
3	Glycogen Synthase (Synthase I)IBA 04/2003 - 01/2002
2	Matrix Metalloproteinase 7 (Matrilysin)IBA 01/2021 - 01/2017
2	Androgen Receptors (Androgen Receptor)IBA 10/2020 - 01/2017
2	Co-Repressor ProteinsIBA 03/2018 - 05/2011
2	Caspase 3 (Caspase-3)IBA 01/2017 - 06/2011
2	SurvivinIBA 01/2017 - 10/2016
2	Cyclin D1IBA 01/2017 - 10/2006
2	Dihydrotachysterol (AT 10)IBA 01/2017 - 07/2013
2	TubulinIBA 07/2011 - 02/2006
2	Proto-Oncogene Proteins c-metIBA 09/2010 - 11/2009
2	Therapeutic UsesIBA 11/2009 - 03/2006
2	AcidsIBA 08/2009 - 07/2009
2	Organoselenium CompoundsIBA 08/2009 - 07/2009
2	Caffeine (No Doz)FDA LinkGeneric 08/2008 - 04/2008
2	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 08/2008 - 01/2006
2	Cadherins (E-Cadherin)IBA 12/2004 - 01/2002
2	Drinking WaterIBA 02/2003 - 09/2002
1	VaccinesIBA 12/2021
1	Immunomodulating AgentsIBA 12/2021
1	6-methylsulfinylhexyl isothiocyanateIBA 03/2021
1	Drug CombinationsIBA 03/2021
1	PorphyrinsIBA 03/2021
1	milbemycin oxime (Interceptor)IBA 03/2021
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2021
1	Linoleic Acid (Linoleate)IBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021
1	Glutamic Acid (Glutamate)FDA Link 01/2021
1	Polysaccharides (Glycans)IBA 01/2021
1	Sirtuin 1IBA 10/2020
1	Circulating Tumor DNAIBA 10/2020
1	Cell-Free Nucleic AcidsIBA 10/2020

Therapy/Procedure

18	Chemoprevention 03/2021 - 02/2006
4	Therapeutics 09/2012 - 04/2006
2	Aftercare (After-Treatment) 03/2021 - 08/2009
2	Drug Therapy (Chemotherapy) 04/2006 - 12/2004
1	Colectomy 01/2021